Mammary and respiratory infection of sheep with H5Nx clade 2.3.4.4b viruses with milk-mediated transmission to lambs
These findings establish sheep as a viable ruminant model for H5N1 and H5N5 infection and highlight previously unidentified transmission dynamics, including milk-mediated and lamb-to-ewe spread.
Cross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune history
Early access - Individuals likely primed in childhood with H1N1 viruses possessed higher levels of antibodies that cross-react with the NA of H5N1 viruses compared to those primed with H2N2 or H3N2 viruses.
Intravenous immunoglobulin treatment for long COVID: a case report of clinical and immunological findings
Immunomodulation could represent a rational therapeutic approach to be evaluated in selected patients.
Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections
AAN-I-IFNs+ patients with life-threatening COVID-19 pneumonia harbor circulating type-I IFN-specific B cells indistinguishable from patients bearing T cell tolerance defects of genetic origin.
Recombinant vs Standard Influenza Vaccine in Adults With Severe Obesity: A Randomized Clinical Trial
In adults living with severe obesity, RIV elicited stronger short-term humoral immune responses than an egg-based standard-dose vaccine, suggesting potential additional benefit for influenza prevention in this vulnerable population.
Dual-route H5N1 vaccination induces systemic and mucosal immunity in murine and bovine models
Vaccine-induced immunity was consistent across species, supporting the translatability of the mouse model findings to cattle.
Characterisation of immune responses targeting highly pathogenic avian influenza A(H5) viruses in health-care workers in the Netherlands: an observational, cross-sectional analysis
An observational, cross-sectional study within the prospective Surveillance of Respiratory Viruses in Healthcare and Animal Workers in the Netherlands (SENTINEL) cohort.
Population immunity to clade 2.3.4.4b H5N1 is dominated by anti-neuraminidase antibodies
Findings indicate that population-level immunity to clade 2.3.4.4b H5 viruses is dominated by NA-directed antibodies, with important implications for pandemic risk assessment.
